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Updated: Oct 21, 2025

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NDK/NME proteins: a host-pathogen interface perspective towards therapeutics.

Ankit Gupta1, Krishna Murari Sinha2, Malik Z Abdin3

  • 1Department of Molecular Medicine, School of Interdisciplinary Sciences and Technology, Jamia Hamdard, New Delhi, 110062, India.

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|September 4, 2021
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Summary

Pathogen Nucleoside diphosphate kinases (NDKs) are promising drug targets for treating parasitic diseases. Comparative analysis reveals potential for broad-spectrum drugs against NDKs, overcoming drug resistance.

Keywords:
LeishmaniaMycobacteriumNDKNMENon-metastatic enzymeNucleoside diphosphate kinase

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Area of Science:

  • Parasitology
  • Drug Discovery
  • Molecular Biology

Background:

  • No effective vaccines exist for parasitic diseases, necessitating new chemotherapy strategies.
  • Drug resistance in pathogens necessitates the identification of novel therapeutic targets.
  • Nucleoside diphosphate kinases (NDKs) are crucial pathogen enzymes that modulate host environments.

Purpose of the Study:

  • To explore pathogen NDKs as novel drug targets for treating parasitic infections.
  • To comparatively analyze the structures and functions of human NMEs and pathogen NDKs.
  • To predict the potential of NDKs as druggable targets for combating multiple pathogens.

Main Methods:

  • Sequence and domain analysis of NDKs and NMEs.
  • Comparative structural and functional analysis.
  • Review of existing literature on NDKs in host-pathogen interactions.

Main Results:

  • NDKs can be classified into two distinct groups based on sequence and domain analysis.
  • One group includes human NMEs 1-4 and NDKs from select parasites and Mycobacterium tuberculosis.
  • The second group includes NME7 and NDKs from other parasites, presenting challenges for selective drug development.

Conclusions:

  • Pathogen NDKs represent a viable target class for developing new anti-parasitic drugs.
  • Targeting group 2 NDKs offers a strategy for broad-spectrum drug development, sparing human NME7.
  • Standardized nomenclature for pathogen NDKs facilitates future research and drug development.