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Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases

Parisa Maleki Dana1, Fatemeh Sadoughi1, Mohammad Ali Mansournia2

  • 1Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

Biogerontology
|September 4, 2021
PubMed

Insights

Polyphenols, found in fruits and vegetables, target molecular pathways like Wnt signaling. This review explores their role in aging and associated diseases, including cancer and Alzheimer's.

Area of Science:

  • Biogerontology
  • Molecular Biology
  • Nutritional Science

Background:

  • Aging shares mechanisms with age-associated diseases.
  • Polyphenols possess antioxidant and anti-inflammatory properties beneficial for chronic diseases.
  • Molecular pathways like mTOR, NF-κB, and Wnt/β-catenin are targeted by polyphenols.

Purpose of the Study:

  • To review the role of polyphenols in targeting Wnt signaling pathways.
  • To examine polyphenol effects in aging processes and age-associated diseases.

Main Methods:

  • Literature review of studies on polyphenols and Wnt signaling.
  • Analysis of pre-clinical investigations on Wnt inhibitors.
  • Synthesis of research on polyphenols in aging and diseases like cancer, diabetes, Alzheimer's, osteoporosis, and Parkinson's.

Main Results:

  • Polyphenols modulate key molecular pathways implicated in aging.
  • Targeting Wnt signaling with polyphenols shows promise in pre-clinical studies.
  • Evidence suggests polyphenols can influence aging and various age-related diseases.

Conclusions:

  • Polyphenols represent a potential therapeutic strategy for aging and associated diseases by targeting Wnt signaling.
  • Further research into polyphenol mechanisms is warranted for age-related conditions.
  • Dietary polyphenols may play a significant role in mitigating age-associated pathologies.
Keywords:
AgingCancerDiabetesNeurodegenerative diseaseOsteopeniaPolyphenolWnt

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