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PFAS and Potential Adverse Effects on Bone and Adipose Tissue Through Interactions With PPARγ
Andrea B Kirk1, Stephani Michelsen-Correa2, Cliff Rosen3
1US Environmental Protection Agency, Washington, District of Columbia 20460, USA.
Endocrinology
|September 4, 2021
Summary
Per- and polyfluoroalkyl substances (PFAS) disrupt cell differentiation, impacting bone development and contributing to metabolic disorders. Understanding these complex effects is crucial for public health risk assessment.
Area of Science:
- Environmental Chemistry
- Toxicology
- Endocrinology
Background:
- Per- and polyfluoroalkyl substances (PFAS) are prevalent synthetic chemicals with widespread environmental distribution.
- PFAS exposure commonly occurs as mixtures, complicating toxicological assessments and risk management.
- These substances exhibit diverse biological effects, notably impacting adipose and bone differentiation.
Purpose of the Study:
- To review the mechanisms by which PFAS affect biological systems, focusing on peroxisome proliferator-activated receptors (PPARs).
- To elucidate the link between PFAS-induced PPAR activation and subsequent effects on cell differentiation and bone development.
- To highlight the public health significance of sensitive endpoints identified in PFAS risk assessments.
Main Methods:
- Literature review of studies investigating PFAS mechanisms of action.
- Analysis of research on PPAR activation by PFAS compounds.
- Examination of data linking PFAS exposure to metabolic and bone health outcomes.
Main Results:
- PFAS activate peroxisome proliferator-activated receptors (PPARs).
- PPAR activation by PFAS leads to altered cell differentiation, affecting bone development.
- These changes contribute to metabolic disorders and compromised bone integrity.
Conclusions:
- PFAS-induced PPAR activation is a key mechanism driving adverse health effects.
- Altered bone development and metabolic dysfunction are significant public health concerns related to PFAS exposure.
- Sensitive endpoints in risk assessments are critical for understanding the full impact of PFAS on health.
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