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Updated: Oct 21, 2025
04:41
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
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Novel targets and therapies for keloid
1Department of Dermatology, Saudi German German Hospitals and Clinics, Dubai, United Arab Emirates.
Clinical and Experimental Dermatology
|September 4, 2021
Summary
Keloids result from abnormal skin scarring due to excess collagen. This review explores emerging treatments like stem cell therapy and gene therapy for keloid management.
Area of Science:
- Dermatology
- Wound Healing
- Regenerative Medicine
Background:
- Keloids are aberrant scars from excessive collagen III during skin healing.
- Genetic predisposition exists, complicating treatment and impacting quality of life.
- Recurrence after surgery is common, necessitating diverse therapeutic strategies.
Purpose of the Study:
- To review keloid development and pathogenesis.
- To assess current and emerging keloid treatment options.
- To explore advancements in keloid therapy, including novel approaches.
Main Methods:
- Literature review of keloid pathogenesis and treatment.
- Analysis of established therapies (corticosteroids, cryotherapy, laser).
- Evaluation of emerging options (stem cells, mitomycin C, gene therapy).
Main Results:
- Keloid formation involves overgrowth of granulation tissue and collagen III.
- Multimodal treatments are often required due to high recurrence rates.
- Emerging therapies show promise in addressing keloid pathology.
Conclusions:
- Understanding keloid pathogenesis is key to developing effective treatments.
- A range of treatments exist, from conventional to advanced regenerative and genetic approaches.
- Future keloid management may involve epigenetic modifications and gene therapy for improved outcomes.
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