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Updated: Oct 21, 2025

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Olmesartan-associated sprue-like enteropathy diagnosed by capsule endoscopy and double balloon endoscopy
Daisuke Taguchi1, Takashi Ibuka2, Masamichi Arao2
1Department of Gastroenterology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu , Gifu, 501-1194, Japan. fiction_may_relieve@yahoo.co.jp.
Abstract:
Sprue-like enteropathy associated with olmesartan is characterized by villous atrophy in the duodenum. We report the case of an 81-year-old woman diagnosed with olmesartan-associated sprue-like enteropathy with no villous atrophy in the duodenum. The patient had been taking olmesartan for 10 years and complained of diarrhea and weight loss. Despite undergoing general treatment for 2 months, her symptoms showed no improvement. Gastrointestinal endoscopy and pathological findings showed no villous atrophy in the duodenum. However, villous atrophy was observed in the small intestine by capsule endoscopy. Pathological biopsy with double balloon endoscopy provided a definitive diagnosis. Diarrhea improved with the discontinuation of olmesartan and weight increased within a week of withdrawal. After the improvement of clinical symptoms, both endoscopic and pathological findings of villous atrophy in small intestine showed improvement.
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