Related Experiment Video
Updated: Oct 21, 2025

09:07
Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
Published on: February 23, 2015
13.6K
[Unipolar depression: a gender-based comparative analysis].
N N Ivanets1, M A Kinkul'kina1, Y G Tikhonova1
1Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|September 5, 2021
Summary
This study reveals significant gender differences in depression. Women with depression were older and had more comorbidities, while men experienced more personality disorders and chronic depression.
Area of Science:
- Psychiatry
- Clinical Psychology
- Mental Health Research
Background:
- Depression is a prevalent mental health condition with varying clinical presentations.
- Understanding gender-specific characteristics of depression is crucial for targeted treatment strategies.
Purpose of the Study:
- To compare socio-demographic and clinical characteristics between men and women diagnosed with unipolar depression.
- To identify gender-based differences in depression symptomatology and comorbidity.
Main Methods:
- A cohort of 388 patients with unipolar depression (74 men, 314 women) was analyzed.
- Data collection involved clinical-psychopathological assessments and validated psychometric depression scales.
Main Results:
- Women with depression were older and more frequently presented with comorbid somatic and organic disorders.
- Men were more likely to have personality disorders and chronic depression.
- Depression severity in women was associated with increased sadness, anxiety, sleep and appetite disturbances, concentration issues, and suicidal ideation.
Conclusions:
- Distinct gender-specific patterns exist in the socio-demographic and clinical profiles of individuals with depression.
- While women reported higher overall depression severity, anhedonia was more pronounced in men.
- These findings underscore the importance of considering gender in the diagnosis and management of depression.
Related Concept Videos
Depressive Disorders: MDD and Dysthymia
250
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
250
Depressive Disorders: Etiology
185
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
185
Depression: Overview
478
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
478
Panic Disorder
235
Panic disorder is an anxiety disorder characterized by recurrent and sudden minutes-long episodes of intense fear, known as panic attacks. These attacks may feel like heart attacks and often happen without warning or a specific cause. They can include symptoms such as rapid heart rate, shortness of breath, chest pain, trembling, sweating, dizziness, and a sense of helplessness. During a panic attack, individuals may feel as though they are experiencing a heart attack or are in a...
235
Bipolar Disorder
189
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
189
Long-term Depression
32.0K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
32.0K

