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Updated: Oct 21, 2025

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
Published on: April 18, 2011
Psychoactive Substance Use Among Individuals With Chronic Spinal Cord Injury: Patterns and Characteristics
Nicole D DiPiro1, James S Krause1
1College of Health Professions, Medical University of South Carolina, Charleston, SC.
Objective:
To identify the patterns of nonprescription psychoactive substance (PAS) use among persons with spinal cord injury (SCI) and the relationships with demographic and injury characteristics.
Design:
Cross-sectional, self-report assessment (SRA).
Setting:
A medical university in the southeastern United States.
Participants:
The participants (N=4670) were identified through a specialty hospital and 2 state-based surveillance registries.
Interventions:
Not applicable.
Main Outcome Measures:
Participants completed SRAs and reported the past 3 months' use of the following substances for which they did not have a prescription: cannabis, cocaine, amphetamine-type stimulants, inhalants, sedatives/hypnotics and sleeping pills, hallucinogens, and opioids. PAS use was grouped into 4 categories: none, cannabis use only, use of cannabis and other PAS, and use of other PAS only.
Results:
Of the 4577 participants who responded to the PAS use questions, 24.1% reported using at least 1 PAS without a prescription. Cannabis was the most frequently reported substance (16.4%), followed by sedatives or sleeping pills (8.0%). By PAS use group, 12.1% reported use of cannabis use only, followed by use of other PAS only (7.7%) and use of cannabis and other PAS (4.3%). There were significant differences among the groups of use by nearly all personal characteristics.
Conclusions:
The use of nonprescription PASs is prevalent among adults with chronic SCI, and there are clear differences in patterns and characteristics of use.
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