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Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and

Zeinab Amini-Farsani1, Mahtab Yadollahi-Farsani2, Samaneh Arab3

  • 1Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran; Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran.

International Immunopharmacology
|September 5, 2021
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of inflammation in COVID-19. Specific miRNAs, like miR-9, can target inflammatory pathways, offering potential therapeutic strategies for COVID-19 complications.

Area of Science:

  • Molecular Biology
  • Immunology
  • Virology

Background:

  • COVID-19 pandemic causes significant morbidity and mortality.
  • Dysregulated inflammation, particularly involving NF-kB and JAK/STAT pathways, contributes to COVID-19 severity.
  • MicroRNAs (miRNAs) are emerging as critical regulators of inflammatory processes.

Purpose of the Study:

  • To review the role of miRNAs in COVID-19-related inflammation.
  • To identify specific miRNAs that modulate key inflammatory pathways.
  • To explore miRNAs as potential therapeutic targets for COVID-19.

Main Methods:

  • Comprehensive literature review of studies on miRNAs and COVID-19 inflammation (Web of Science, PubMed, Scopus).
  • Analysis of inflammatory gene interactions using STRING DB.
  • Design of miRNA-target gene interactions using Cityscape software.

Main Results:

  • Several miRNAs, including miR-9, miR-98, miR-223, and miR-214, were identified as crucial regulators.
  • These miRNAs significantly influence the NF-kB and JAK-STAT signaling pathways.
  • Perturbations in these miRNA levels are linked to the onset and severity of COVID-19.

Conclusions:

  • Specific miRNAs play a vital role in managing inflammatory responses in COVID-19.
  • Targeting these miRNAs (e.g., miR-9, miR-98, miR-223, miR-214) presents a promising avenue for developing novel therapeutics.
  • Further research into miRNA-based therapies could mitigate COVID-19 complications.
Keywords:
COVID-19InflammationJAK/STATNF-kBmiRNA

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