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Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...

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Related Experiment Video

Updated: Oct 21, 2025

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Emerging imaging methods to study whole-brain function in rodent models.

Marija Markicevic^1,2, Iurii Savvateev^1,2,3, Christina Grimm^1,2

¹Neural Control of Movement Lab, HEST, ETH Zürich, Zürich, Switzerland.

Translational Psychiatry

|September 5, 2021

Summary

This summary is machine-generated.

Understanding brain networks requires advanced imaging. This review covers emerging preclinical brain imaging methods for studying neural activity and network interactions in rodents, aiding research choices.

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Last Updated: Oct 21, 2025

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Published on: February 24, 2021

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Area of Science:

Neuroscience
Biomedical Engineering
Cognitive Science

Background:

The understanding of cognition and behavior has shifted from single neuron populations to the importance of network connectivity.
Advancements in brain imaging techniques offer tools to study functional organization in complex neural networks.
Existing imaging tools present technical challenges and limitations requiring careful consideration of their specificity.

Purpose of the Study:

To review emerging methods for measuring spontaneous or evoked brain activity.
To focus on techniques with high temporal resolution (milliseconds to seconds) for large-scale brain activity measurement.
To provide an overview of preclinical imaging methods for the mammalian brain (mice and rats) and future outlooks.

Main Methods:

Review of emerging imaging techniques for measuring brain activity in preclinical models.
Discussion of methods with high temporal resolution for large-scale neural network analysis.
Focus on techniques applicable to rodent models (mice and rats).

Main Results:

Emerging methods allow measurement of spontaneous or evoked brain activity with high temporal resolution.
Innovations in gene-editing and invasive recording techniques facilitate advanced preclinical brain studies.
A range of imaging tools are available for characterizing functional organization in complex brain networks.

Conclusions:

Preclinical brain imaging methods are rapidly evolving, driven by technological innovations.
Careful consideration of method-specific challenges is crucial for accurate interpretation of neural network function.
This review serves as an educational resource for scientists selecting appropriate imaging methods for their research questions.