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Indolent T-lymphoblastic proliferation: a report of three cases
Zheng Yuanyuan1, Xie Jianlan1, Zhang Yanlin1
1Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People's Republic of China.
Virchows Archiv : an International Journal of Pathology
|September 5, 2021
Summary
Indolent T-lymphoblastic proliferation (iT-LBP), a T-cell disorder, is newly associated with both benign reactive lymphoid hyperplasia and malignant lymphomas. This finding expands understanding of iT-LBP
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Indolent T-lymphoblastic proliferation (iT-LBP) is characterized by extrathymic proliferation of nonclonal TdT+ T cells.
- iT-LBP is typically associated with lymphoid disorders, but its co-occurrence with lymphoma is rarely reported.
Observation:
- This study presents three cases of concurrent iT-LBP with lymphoid disorders.
- Case 1 involved iT-LBP with benign reactive lymphoid hyperplasia in cervical lymph nodes.
- Cases 2 and 3 demonstrated iT-LBP alongside peripheral T-cell lymphoma and follicular lymphoma, respectively.
Findings:
- Polyclonal precursor T-cells in iT-LBP were observed distributed within both benign hyperplastic and neoplastic lymphoid follicles.
- The neoplastic follicles in Case 2 comprised CD4+ and CXCL13+ T-cells.
Implications:
- These findings suggest a potential association between iT-LBP and both reactive lymphoid hyperplasia and various types of lymphoma.
- This expands the known spectrum of lymphoid disorders associated with iT-LBP.
- Further research is warranted to elucidate the pathogenetic mechanisms underlying this association.
