Negative Correlation Between Circular RNA SMARC5 and MicroRNA 432, and Their Clinical Implications in Bladder Cancer...

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Bladder cancer is a significant global health concern.
• Identifying reliable prognostic markers is crucial for improving patient outcomes.

Purpose of the Study:

• To investigate the correlation of circular RNA SMARCA5 (circ-SMARCA5) and microRNA 432 (miR-432) with clinical characteristics and survival in bladder cancer patients.

Main Methods:

• Retrospective review of 156 bladder cancer patients' clinicopathologic and survival data.
• Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect circ-SMARCA5 and miR-432 expression in tumor and adjacent tissues.

Main Results:

• Circ-SMARCA5 was upregulated, while miR-432 was downregulated in bladder tumor tissues.
• High circ-SMARCA5 expression correlated with larger tumor size, advanced stage, and lymph node metastasis.
• High miR-432 expression correlated with smaller tumor size, lower stage, and less metastasis.
• High circ-SMARCA5 expression was associated with shorter disease-free survival (DFS) and overall survival (OS).
• High miR-432 expression was associated with longer DFS and OS.
• Circ-SMARCA5 was identified as an independent predictive factor for worse DFS and OS.

Conclusions:

• Elevated circ-SMARCA5 and decreased miR-432 expression are linked to aggressive tumor features and poor prognosis in bladder cancer.
• Circ-SMARCA5 and miR-432 show potential as prognostic biomarkers for bladder cancer.