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Related Experiment Video

Updated: Oct 21, 2025

Modified Blood Collection from Tail Veins of Non-anesthetized Mice with a Vacuum Blood Collection System and Eyeglass Magnifier

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Performance of 3 mL versus 5 mL Discarded Volume for Blood Sampling from Central Venous Access Device.

H T Lalthanthuami¹, M J Kumari², R Venkateswaran³

¹Department of Medical Surgical Nursing, College of Nursing, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Journal of Laboratory Physicians

|September 6, 2021

Summary

This summary is machine-generated.

Reducing discard volume in central venous access device (CVAD) blood sampling from 5 mL to 3 mL can significantly decrease iatrogenic blood loss in critical care patients without compromising sample integrity.

Keywords:

blood discards blood sampling central lines central venous access device critical care diagnostic blood loss discarded volume

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Area of Science:

Critical Care Medicine
Laboratory Hematology
Nursing Practice

Background:

Central venous access devices (CVADs) are crucial for venous access in critical care.
The discard method for blood sampling can lead to cumulative, clinically significant blood loss.
Optimizing discard volume is essential to minimize iatrogenic blood loss and ensure sample quality.

Purpose of the Study:

To compare the impact of 3 mL versus 5 mL discard volumes on serum parameter accuracy.
To evaluate the potential for reducing diagnostic blood loss during CVAD sampling.
To ensure subsequent blood samples are not diluted or contaminated.

Main Methods:

A within-subjects comparative design involving 64 medical intensive care unit patients.
Collection of paired blood samples using 3 mL and 5 mL discard volumes from each patient.
Measurement and comparison of six key serum parameters between the two discard methods.

Main Results:

No statistically significant difference in fixed bias between 3 mL and 5 mL discard methods.
Potassium and creatinine showed significant proportional bias; agreement limits for sodium, potassium, creatinine, and direct bilirubin were outside clinical intervals but affected <10% of samples.
Excellent reliability was observed for most serum parameters, with good reliability for sodium.

Conclusions:

Discarding 3 mL of blood is recommended over 5 mL to reduce iatrogenic blood loss.
Critical care nurses play a key role in minimizing diagnostic blood loss during blood sampling.
Reducing discard volume offers a practical strategy to improve patient safety and resource management.