Low-grade fibromyxoid sarcoma: A rare case report.

Area of Science:

• Oncology
• Pathology
• Surgical Oncology

Background:

• Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue neoplasm with deceptively benign histologic features but a propensity for metastasis.
• While typically affecting the deep soft tissues of the trunk and extremities in adults, LGFMS rarely occurs in the maxillofacial region.

Observation:

• A case of LGFMS in the left lower face of a 35-year-old male is presented, with a 6-month history.
• Gross examination revealed a 2 cm × 2 cm × 1 cm ovoid mass. Histopathology showed a well-circumscribed myxoid tumor with areas of hypocellularity and collagenization.

Findings:

• Immunohistochemical analysis demonstrated diffuse vimentin positivity and negative staining for desmin and S-100 protein, confirming the LGFMS diagnosis.
• The patient underwent surgical excision followed by 30 cycles of radiotherapy. No recurrence or metastasis was observed at 1-year follow-up.

Implications:

• This case underscores the importance of recognizing LGFMS in unusual locations like the maxillofacial region.
• The indolent yet metastatic nature of LGFMS necessitates long-term clinical follow-up to monitor for potential recurrence or distant spread.