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Drug-Induced Liver Disturbance During the Treatment of COVID-19

Guanghua Zhai1, Meifen Li1, Ying Wang2

  • 1Department of Clinical Laboratory, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China.

Frontiers in Pharmacology
|September 6, 2021
PubMed

Insights

This review examines how COVID-19 treatments affect liver function. It aims to clarify the link between medications and liver disturbance in patients with coronavirus disease 2019.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, has been associated with various degrees of liver injury in patients.
  • The specific impact of COVID-19 treatments on hepatic function remains a subject of ongoing research and clinical debate.

Purpose of the Study:

  • To analyze the effects of different drugs used in COVID-19 treatment on liver function.
  • To provide evidence-based guidance for clinical practice regarding drug-induced liver injury in COVID-19 patients.

Main Methods:

  • A comprehensive review of existing literature was conducted.
  • Studies investigating the relationship between therapeutic agents and hepatic function during COVID-19 treatment were analyzed.

Main Results:

  • The review synthesizes findings on the hepatotoxicity of various medications employed for COVID-19.
  • Identifies specific drugs and drug classes associated with potential liver disturbances.

Conclusions:

  • Understanding drug-induced liver injury is crucial for managing COVID-19 patients safely.
  • This review offers insights to guide clinicians in selecting treatments that minimize risks to hepatic function.
Keywords:
coronavirus disease 2019drugsliver disturbancesevere acute respiratory syndrome coronavirus 2treatment

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