Mantle cell lymphoma involving the thyroid gland

Area of Science:

• Oncology
• Nuclear Medicine
• Endocrinology

Background:

• Mantle cell lymphoma (MCL) is an uncommon non-Hodgkin lymphoma.
• Thyroid gland involvement by MCL is a rare clinical presentation.
• Accurate diagnosis of extranodal lymphoma is essential for appropriate patient management.

Observation:

• Positron emission tomography-computed tomography (PET-CT) is a key imaging modality in lymphoma staging and assessment.
• The study investigates the utility of PET-CT in identifying MCL involvement of the thyroid gland.
• Thyroid function tests may not correlate with the presence or extent of MCL infiltration.

Findings:

• PET-CT can effectively identify thyroid gland abnormalities suggestive of MCL infiltration.
• Imaging findings on PET-CT are critical for detecting rare thyroid involvement by MCL.
• The diagnostic value of PET-CT is independent of thyroid function test results.

Implications:

• Early and accurate identification of thyroid MCL involvement can be achieved using PET-CT.
• PET-CT facilitates targeted workup and biopsy of suspicious thyroid lesions.
• This approach improves the diagnostic yield for rare extranodal presentations of MCL.