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High-Sensitivity Cardiac Troponin T Is a Risk Factor for Major Adverse Cardiovascular Events and All-Cause Mortality:

Xiaona Wang1, Peiqi Wang2, Ruihua Cao1

  • 1Department of Geriatric Cardiology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.

Cardiology Research and Practice
|September 6, 2021
PubMed

Insights

High-sensitivity cardiac troponin T (hs-cTnT) is a risk factor for major adverse cardiovascular events and all-cause mortality in the Chinese population. This study confirms hs-cTnT

Area of Science:

  • Cardiology
  • Biomarkers
  • Population Health

Background:

  • Controversial findings exist regarding high-sensitivity cardiac troponin T (hs-cTnT) and cardiovascular events in global studies.
  • No prior longitudinal studies on hs-cTnT in the Chinese population.

Purpose of the Study:

  • To investigate the association between plasma hs-cTnT levels and major adverse cardiovascular events (MACEs) and all-cause mortality.
  • To establish hs-cTnT as a potential risk factor in the Chinese community-based population.

Main Methods:

  • Longitudinal follow-up of 1325 subjects in Beijing, China.
  • Analysis of plasma hs-cTnT levels.
  • Cox proportional hazards models and ROC curve analysis were used to assess associations with MACEs, coronary events, and mortality.

Main Results:

  • Increased hs-cTnT levels significantly correlated with a higher risk of MACEs (HR 1.223, P=0.008) and coronary events (HR 1.391, P=0.005).
  • Elevated hs-cTnT levels were associated with increased all-cause mortality risk (HR 1.763, P=0.002), even after adjusting for hs-CRP and NT-proBNP.
  • ROC analysis demonstrated predictive value for MACEs, coronary events, and mortality (AUCs 0.559, 0.629, and 0.644, respectively).

Conclusions:

  • Plasma hs-cTnT is a significant risk factor for major adverse cardiovascular events in the Chinese population.
  • Elevated hs-cTnT levels predict increased risk of all-cause mortality in this cohort.
  • Findings support the clinical utility of hs-cTnT for cardiovascular risk stratification in China.
Abstract

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