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An attempt to quantify magnetic resonance imaging in multiple sclerosis--correlation with clinical parameters
1Max Planck-Gesellschaft, Clinical Research Unit for Multiple Sclerosis, Würzburg, West Germany.
Abstract:
The diagnostic value of magnetic resonance imaging (MRI) in multiple sclerosis (MS) is uncontested. But only little information exists on its usefullness in monitoring disease activity. We describe a method of quantification that can be performed in longitudinal MRI-investigations. We used a standardized method of scanning and determined the area of demyelinating lesions with an interactive planimetric computer system. In order to determine the approximate lesion volumes, the computed area was multiplied by the slice thickness. In 89 patients with clinically definite MS we found an average lesion volume of 11900 mm3. The mean score in Kurtzke's expanded disability scale was 3.0. The correlation between computed lesion volume and neurological deficit was significant, but only weak (rho = 0.3). We conclude, that planimetric evaluation of MRI can be a valuable supplement to clinical rating scales in MS patients. The method described here, used in combination with high spacial resolution and better tissue specificity of latest generation MRI scanners, could be helpful in the evaluation of treatment in many other CNS diseases.
Insights
Magnetic resonance imaging (MRI) can quantify multiple sclerosis (MS) lesion volume. This planimetric MRI method aids in monitoring disease activity and may assist in evaluating treatments for central nervous system diseases.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Magnetic resonance imaging (MRI) is crucial for diagnosing multiple sclerosis (MS).
- Limited data exists on MRI's utility in monitoring MS disease activity over time.
- Quantitative MRI methods are needed for objective disease assessment.
Purpose of the Study:
- To describe and evaluate a quantitative method for assessing demyelinating lesion volume in MS using MRI.
- To correlate lesion volume with clinical disability scores in MS patients.
Main Methods:
- A standardized MRI scanning protocol was employed.
- An interactive planimetric computer system quantified lesion area.
- Lesion volume was calculated by multiplying area by slice thickness.
Main Results:
- Eighty-nine patients with clinically definite MS were analyzed.
- Average lesion volume was 11900 mm3, with a mean Kurtzke expanded disability scale score of 3.0.
- A weak but significant correlation (rho = 0.3) was found between lesion volume and neurological deficit.
Conclusions:
- Planimetric MRI evaluation is a valuable supplement to clinical rating scales for MS.
- This quantitative method, combined with advanced MRI technology, shows promise for evaluating treatments in various central nervous system diseases.