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Viral Coinfection among COVID-19 Patient Groups: An Update Systematic Review and Meta-Analysis
Pooneh Malekifar1, Reza Pakzad2,3, Ramin Shahbahrami4
1Department of Epidemiology, School of Public Health, Tehran University Medical Sciences, Tehran, Iran.
Biomed Research International
|September 6, 2021
Summary
Viral coinfections in COVID-19 patients were evaluated, revealing an overall prevalence of 12.58%. Blood-borne viruses were most common, while respiratory viruses were least frequent, impacting patient treatment strategies.
Area of Science:
- Infectious Diseases
- Virology
- Epidemiology
Background:
- Coinfections can exacerbate morbidity and mortality during pandemics.
- Understanding viral coinfection in COVID-19 is crucial for patient management.
Purpose of the Study:
- To evaluate the prevalence of viral coinfections in patients diagnosed with COVID-19.
- To identify the types of viruses most frequently co-infecting COVID-19 patients.
Main Methods:
- Systematic literature search of Medline, Scopus, WOS, and Embase databases (Dec 2019–Dec 2020).
- Inclusion of preprint servers (e.g., medRxiv) and all study types assessing viral coinfection in COVID-19.
- Application of a random effects model for meta-analysis of pooled prevalence.
Main Results:
- Thirty-three studies comprising 10,484 patients were analyzed.
- The overall pooled prevalence of viral coinfection in COVID-19 patients was 12.58%.
- Blood-borne viruses showed the highest prevalence (12.48%), followed by respiratory viruses (4.32%). Herpesvirus prevalence was 11.71%.
Conclusions:
- Respiratory viruses had the lowest coinfection rate among COVID-19 patients.
- Blood-borne viruses represent the most significant coinfection concern.
- Findings offer critical data for optimizing COVID-19 treatment protocols.
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