Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

17.7K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
17.7K
Positron Emission Tomography01:29

Positron Emission Tomography

6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Computed Tomography01:10

Computed Tomography

7.1K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.1K
Photoluminescence: Applications01:14

Photoluminescence: Applications

563
Photoluminescence offers a wide range of applications due to its inherent sensitivity and selectivity. This technique allows for both direct and indirect analyses of the analyte. Direct quantitative analysis is possible when the analyte exhibits a favorable quantum yield for fluorescence or phosphorescence. However, an indirect analysis may be feasible if the analyte is not fluorescent or phosphorescent, or if the quantum yield is unfavorable. Indirect methods include reacting the analyte with...
563

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical benefits and current challenges of photon-counting detector CT in vascular imaging.

Radiology advances·2026
Same author

Hallucination at low radiation dose: Evaluation of two deep-learning reconstruction methods in high-resolution chest CT.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same author

Accuracy and precision of automated kidney stone detection on CT.

Abdominal radiology (New York)·2026
Same author

The Uncoupling of CT Dose and Noise.

Radiology·2026
Same author

A framework for quantifying and leveraging uncertainty in pre-trained CT denoising model.

IEEE transactions on bio-medical engineering·2026
Same author

Mitigating CT number variability between scanners, tube potentials, and patient sizes using spectral CT virtual monoenergetic imaging.

Physics in medicine and biology·2026
Same journal

Impact of DOI Capability on Detector Performance: A Comparative Study of DOI and Non-DOI Detectors for High-Resolution and Sensitivity Organ-Specific PET Inserts.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

Evaluation of a PET Insert for Trimodal Imaging: A Step Toward PET/MRI-Guided Focused Ultrasound.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

CHEMONO: a Cherenkov-Only Monolithic Detector for PGI in Proton Range Verification.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

A Virtual Clinical Trial to Detect Changes in Tumor Uptake with PET using Lesion Embedding.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

Quantitative evaluation of spatially-variant deformations recovered by deep learning on clinical-like breast lesions.

IEEE transactions on radiation and plasma medical sciences·2026
Same journal

Impact of detector parameters and image resolution modeling on dedicated brain PET imaging.

IEEE transactions on radiation and plasma medical sciences·2026
See all related articles

Related Experiment Video

Updated: Oct 21, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

12.6K

Photon Counting CT: Clinical Applications and Future Developments.

Scott S Hsieh1, Shuai Leng1, Kishore Rajendran1

  • 1Department of Radiology at the Mayo Clinic, Rochester MN 55905 USA.

IEEE Transactions on Radiation and Plasma Medical Sciences
|September 6, 2021
PubMed
Summary
This summary is machine-generated.

Photon counting detector CT (PCD CT) offers spectral information, immunity to electronic noise, and high resolution. This technology improves artifact reduction, characterization of incidental findings, and visualization of structures like the temporal bone at lower doses.

Keywords:
clinical applicationsphoton counting X-ray detectorsspectral CT

More Related Videos

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
09:43

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

11.8K
A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting
08:57

A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting

Published on: March 9, 2017

8.6K

Related Experiment Videos

Last Updated: Oct 21, 2025

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers
12:24

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

12.6K
Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging
09:43

Hand-held Clinical Photoacoustic Imaging System for Real-time Non-invasive Small Animal Imaging

Published on: October 16, 2017

11.8K
A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting
08:57

A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting

Published on: March 9, 2017

8.6K

Area of Science:

  • Medical Imaging
  • Radiology
  • Detector Technology

Background:

  • Conventional energy integrating detectors (EIDs) in CT have limitations.
  • Photon counting detectors (PCDs) represent a significant advancement in CT technology.
  • PCD CT is under intense investigation for clinical applications.

Purpose of the Study:

  • To review potential clinical applications of PCD CT.
  • To highlight institutional experience with a prototype PCD CT scanner.
  • To discuss the advantages and future potential of PCD CT.

Main Methods:

  • Review of existing literature and institutional experience.
  • Focus on the technical advantages of PCDs over EIDs.
  • Exploration of clinical use cases and future developments.

Main Results:

  • PCDs offer spectral information, electronic noise immunity, and high resolution.
  • PCD CT can mitigate metal artifacts, beam hardening, and photon starvation.
  • Spectral information aids in characterizing incidental findings.
  • High-resolution visualization of structures like the temporal bone is improved at reduced dose.

Conclusions:

  • PCD CT offers significant advantages over conventional CT detectors.
  • The technology shows promise for improved image quality, artifact reduction, and dose efficiency.
  • Future developments in PCD CT and contrast agents are anticipated to expand clinical utility.