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Updated: Oct 21, 2025

Production of Elastin-like Protein Hydrogels for Encapsulation and Immunostaining of Cells in 3D

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Published on: May 19, 2018

Novel Protein Therapeutics Created Using the Elastin-Like Polypeptide Platform.

Gene L Bidwell¹

¹Departments of Neurology, Cell and Molecular Biology, and Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi.

Physiology (Bethesda, Md.)

|September 6, 2021

Summary

Elastin-like polypeptides (ELPs) offer a unique thermally triggered property for advanced drug delivery. These versatile ELP-fusion proteins show promise as targeted carriers and depots for biologics development.

Keywords:

controlled release depot drug delivery elastin-like polypeptide nanoparticle

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Design and Construction of Artificial Extracellular Matrix aECM Proteins from Escherichia coli for Skin Tissue Engineering

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Area of Science:

Biotechnology
Materials Science
Pharmaceutical Sciences

Background:

Elastin-like polypeptides (ELPs) are bioengineered proteins with a unique inverse phase transition property.
This thermal property allows for precise control over ELP solubility and aggregation.

Purpose of the Study:

To explore the application of ELP-based systems for drug delivery.
To highlight the versatility of ELP-fusion proteins in various drug delivery strategies.

Main Methods:

Utilizing the thermally triggered phase transition of ELPs.
Developing ELP-fusion proteins for specific drug delivery applications.

Main Results:

ELP-fusion proteins demonstrated utility as soluble biologics.
ELPs function effectively as thermally targeted drug carriers.
Self-assembling ELP nanoparticles and slow-release depots were achieved.

Conclusions:

ELP-based drug delivery systems offer a promising platform for biologics.
The unique characteristics of ELPs enable versatile delivery of diverse therapeutics.