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Updated: Oct 21, 2025

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Published on: August 16, 2018
Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials
Sai Varshini Magham1, Praveen Thaggikuppe Krishnamurthy1, Neenu Shaji1
1Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, India.
Abstract:
Endocannabinoid system has been extensively studied in recent decades, particularly the cannabinoid receptors CB1 and CB2, due to their important role in neuroinflammation. Among these, CB2 has gained prominence due to its selective overexpression in glial cells during neuroinflammation. In contrast to CB1 agonists, CB2 agonists have no side effects such as ataxia, hypothermia, euphoria, psychological, or addiction liabilities. CB2 and its selective agonists' above-mentioned unique properties have become a research focus in neurodegenerative disorders such as Alzheimer's disease (AD). The review discusses the neuroprotective role of CB receptors, particularly CB2, in AD, as well as the significance and limitations of this research.
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