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Updated: Oct 21, 2025
Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Psychiatric comorbidities of obsessive-compulsive disorder: A series of systematic reviews and meta-analyses
Charlotte Rowe1, Aurore Deledalle1, Abdel Halim Boudoukha1
1Laboratoire de Psychologie des Pays de la Loire LPPL-EA4638, Faculté de Psychologie, Université de Nantes, Nantes, France.
Objective:
Although there is a growing number of studies on psychiatric comorbidities of obsessive-compulsive disorder (OCD), controversy remains about the strength of associations between some disorders. We present a series of systematic reviews and meta-analyses examining four psychiatric disorders frequently associated with OCD-depression, bipolar disorder, substance abuse disorder and psychosis.
Methods:
Three electronic databases were searched up to May 2017; PsycINFO, Medline, and Web of Science. Meta-analyses using random effects models were conducted.
Results:
The meta-analyses found strong associations between all comorbidities and OCD, particularly for depression. In addition, a series of systematic reviews were conducted giving information about the characteristics of these psychiatric associations.
Conclusion:
It is probable that these disorders share common etiological factors, and thus trans-diagnostic processes must be addressed when offering treatment. Clinical implications of these findings are discussed with suggestions for further research in the area.
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