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Is there an association between urine biochemical parameters on admission and the severity OF COVID-19?

Omer Erdogan1, Fesih Ok1, Serkan Carkci1

  • 1Urology Department, Siirt Training and Research Hospital, Siirt, Turkey.

International Journal of Clinical Practice
|September 6, 2021
PubMed

Insights

Urinary findings like proteinuria are linked to COVID-19 severity. This study highlights how simple urine tests can help predict disease progression in coronavirus disease-2019 (COVID-19) patients.

Area of Science:

  • Medical Research
  • Biochemistry
  • Infectious Diseases

Background:

  • Coronavirus disease-2019 (COVID-19) poses a significant global health challenge.
  • Understanding predictors of COVID-19 severity is crucial for patient management.
  • Urinary biochemical parameters have not been extensively studied in relation to COVID-19 severity.

Purpose of the Study:

  • To investigate the association between urinary biochemical parameters and the severity of COVID-19.
  • To identify potential urine markers for predicting COVID-19 disease progression.

Main Methods:

  • Retrospective analysis of 133 COVID-19 patients categorized by disease severity (moderate, severe, critical) and 50 healthy controls.
  • Evaluation of various urine biochemical parameters including specific gravity, pH, erythrocyturia, proteinuria, and glucosuria.
  • Correlation and multivariate analyses to determine the relationship between urinary parameters and disease severity.

Main Results:

  • COVID-19 patients showed significantly higher rates of erythrocyturia, proteinuria, and glucosuria compared to controls.
  • Lower urine specific gravity and higher pH were observed in patients.
  • Proteinuria, age, elevated respiratory rate, and low oxygen saturation (SpO2) were identified as independent predictors of COVID-19 severity.

Conclusions:

  • Proteinuria, a readily assessable parameter in routine urinalysis, may serve as an indicator of COVID-19 severity.
  • Urinary biochemical analysis offers a potential tool for early risk stratification in COVID-19 patients.
  • Further research is warranted to validate these findings and explore the underlying mechanisms.
Abstract

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