Analysis of corneal densitometry and endothelial morphometry in patients with psoriasis

To evaluate corneal endothelial properties and corneal densitometry values in patients with psoriasis and to compare the results with those of healthy controls.

This prospective, comparative, and cross-sectional study included 106 eyes of 53 patients who were diagnosed with psoriasis and 106 eyes of 53 age-gender matched healthy controls. All patients were evaluated in terms of ocular surface tests such as Schirmer-1 and tear break-up time (TBUT). Corneal endothelial measurements were performed using noncontact specular microscopy. Corneal tomographic and densitometric measurements were obtained using the Scheimpflug imaging system. Measurements were also evaluated according to the psoriasis area and severity index (PASI) score.

The mean TBUT and Schirmer 1 test values were significantly lower in the psoriasis group than in the healthy controls (p = 0.02, p < 0.001, respectively). While the mean endothelial cell density was significantly lower in patients with psoriasis than the healthy controls (2389.9±314.9 cells/mm² vs. 2512.4±289.7 cells/mm², p = 0.02), the mean average endothelial cell area, standard deviation of cell area, coefficient of variation of cell area were significantly higher in patients with psoriasis (426.6±62.7 µm² vs. 403.2±46.1 µm², p = 0.01; 206.4±52.3 µm² vs. 183.2±43.8 µm², p = 0.006; and 48.1±6.3% vs. 45.7±6.7%, p = 0.04, respectively). Most of the densitometry measurements in concentric zones were higher in patients with psoriasis than in healthy controls, but none of the differences reached statistical significance.

A regular eye examination is crucial in patients with psoriasis because corneal structural and functional changes, particularly endothelial alterations, are of utmost importance in planning intraocular surgeries in patients with psoriasis.