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Naturally occurring physalins from the genus Physalis: A review
Jiangping Wu1, Jianping Zhao2, Tao Zhang1
1Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China.
Phytochemistry
|September 6, 2021
Summary
Physalins, unique steroids from Physalis plants, exhibit diverse pharmacological activities. This review covers their phytochemistry, pharmacology, and applications in China from 1970-2021.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Physalins are highly oxygenated ergostane-type steroids, also known as 16,24-cyclo-13,14-seco steroids.
- These compounds are characteristic constituents of the genus Physalis (Solanaceae).
- Physalins possess a broad spectrum of reported pharmacological activities.
Purpose of the Study:
- To systematically review research progress on physalins from the genus Physalis.
- To cover phytochemistry, pharmacology, pharmacokinetics, and applications in China.
- To focus on the period from 1970 to 2021.
Main Methods:
- Literature review and systematic analysis of research publications.
- Compilation of data on physalin structures and their isolation.
- Summarization of pharmacological studies and pharmacokinetic data.
- Discussion of applications in traditional and modern medicine.
Main Results:
- Detailed description of the structural characteristics of physalins and neophysalins.
- Compilation of diverse pharmacological activities including anticancer, anti-inflammatory, and antimicrobial effects.
- Summary of pharmacokinetic profiles and metabolic pathways.
- Overview of applications in treating various diseases.
Conclusions:
- Physalins represent a significant class of bioactive natural products with therapeutic potential.
- Continued research in phytochemistry and pharmacology is crucial for unlocking their full medicinal value.
- This review provides a comprehensive resource for understanding physalin research in China.
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