Structural brain correlates of eating pathology symptom dimensions: A systematic review

There has been an increasing interest in neurobiological correlates of psychopathology with a growing consensus that such research questions are best investigated through dimensional approaches to psychopathology. One area that has been noticeably understudied in this regard is eating pathology. Therefore, the goal of the current systematic review was to summarize research on structural brain correlates of symptom dimensions of eating-related pathology. Google Scholar and PubMed databases were searched following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results suggest that restrained eating is associated with increased GMV (gray matter volume) in regions involved in emotional, visuo-spatial, attentional, and self-related processing. Disinhibitory eating is associated with increased GMV in regions involved in reward value of food-related stimuli and decreased GMV in regions involved in emotional/motivational processing. All told, results suggest that dimensions of eating pathology have differential neuroanatomical correlates potentially suggesting differences in neural pathways which has the potential to support future biologically-driven classification and treatment efforts.