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Related Experiment Video

Updated: Oct 21, 2025

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

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Visual fields and optical coherence tomography (OCT) in neuro-ophthalmology: Structure-function correlation.

Laura Donaldson¹, Edward Margolin²

¹University of Toronto, Faculty of Medicine, Department of Ophthalmology and Vision Sciences, Toronto, Ontario, Canada.

Journal of the Neurological Sciences

|September 6, 2021

Summary

This summary is machine-generated.

Visual field (VF) testing and optical coherence tomography (OCT) together improve lesion localization in the visual pathway. OCT reveals structural changes like retinal nerve fibre layer thinning, aiding diagnosis of neurological conditions affecting vision.

Keywords:

Ganglion cell analysis Optical coherence tomography Visual field Visual field interpretation

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Area of Science:

Neuroscience
Ophthalmology
Neurology

Background:

Visual field (VF) testing is crucial for neurological exams.
Optical coherence tomography (OCT) provides detailed structural evaluation of the optic nerve and retina.
Relating VF defects to visual pathway structure aids diagnosis.

Purpose of the Study:

To describe how combining VF and OCT interpretation enhances lesion localization accuracy.
To correlate specific VF defects with OCT findings in visual pathway disorders.

Main Methods:

Review of existing literature on VF testing and OCT interpretation.
Analysis of how structural changes (OCT) relate to functional deficits (VF).
Correlation of lesion location with characteristic VF patterns and OCT biomarkers.

Main Results:

Anterior visual pathway lesions cause midline-respecting VF defects and retinal nerve fibre layer thinning on OCT.
Chiasmal lesions present as junctional scotomas or bitemporal hemianopia with nasal ganglion cell complex thinning.
Optic tract lesions yield incongruous homonymous hemianopia and delayed GCC thinning; optic radiation lesions cause more congruous defects and much later GCC thinning.

Conclusions:

Integrated VF and OCT analysis significantly improves the accuracy of localizing visual pathway lesions.
OCT provides objective structural evidence supporting functional VF deficits, aiding differential diagnosis.
Understanding the timing of structural changes (GCC thinning) aids in differentiating lesion chronicity and location.