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Suicidality in patients with premenstrual dysphoric disorder-A systematic review and meta-analysis

Haohao Yan1, Yudan Ding1, Wenbin Guo2

  • 1National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.

Journal of Affective Disorders
|September 6, 2021
PubMed
Abstract

Insights

Premenstrual dysphoric disorder (PMDD) significantly increases the risk of suicidal ideation, attempts, and plans. Vigilance for suicidal behavior is crucial for effective PMDD treatment and prevention.

Area of Science:

  • Reproductive Psychiatry
  • Mental Health Research
  • Clinical Epidemiology

Background:

  • Premenstrual dysphoric disorder (PMDD) is a severe mood disorder impacting women's health.
  • The correlation between PMDD and suicidality remains incompletely understood.
  • Existing research lacks comprehensive analysis of PMDD's impact on suicide risk.

Purpose of the Study:

  • To systematically evaluate the association between Premenstrual Dysphoric Disorder (PMDD) and suicidality.
  • To quantify the risk of suicidal ideation, attempts, and plans in individuals with PMDD.
  • To synthesize evidence from existing studies to clarify PMDD's role in suicide risk.

Main Methods:

  • A meta-analysis was conducted using data from six studies.
  • Searches were performed across Scopus, Embase, PubMed, and Web of Science databases.
  • Quality assessment, data synthesis, and sensitivity analyses were applied to included studies.

Main Results:

  • PMDD was linked to a 2.34-fold increased risk of suicidal ideation.
  • Individuals with PMDD showed a 2.13-fold higher risk of suicide attempts.
  • A 2.24-fold increased risk of suicidal plans was observed in the PMDD group.

Conclusions:

  • A subset of women with PMDD experiences particularly high suicidal risk.
  • Clinicians must remain vigilant for suicidal ideation and behavior in PMDD patients.
  • Enhanced monitoring and preventive strategies are essential for managing PMDD-associated suicidality.
Keywords:
Premenstrual dysphoric disorderSuicidal ideationSuicidal planSuicidalitySuicide attempt

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