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Updated: Oct 21, 2025

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs
Published on: November 17, 2023
A surface-imprinted surface-enhanced Raman scattering sensor for histamine detection based on dual semiconductors and
Chen Chen1, Ximo Wang1, Geoffrey I N Waterhouse2
1Key Laboratory of Food Processing Technology and Quality Control in Shandong Province, College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China.
Abstract:
A highly sensitive molecularly imprinted surface-enhanced Raman scattering (SERS) sensor was developed for selective detection of histamine. A combination of two semiconductors and Ag nanoparticles (NPs) was used as the SERS substrate. The SERS was induced by Ag NPs plasmon resonances as well as charge-transfer between the semiconductors and the Ag NPs. The Raman intensity and the logarithm of the histamine concentration were linear over the range 10-8-10-3 mol L-1. The sensor exhibited good selectivity and had a sensitivity limit of 3.088 × 10-9 mol L-1. Histamine was detected in a spiked liquor sample, and its recoveries were in the range of 89.89%-109.18%.

