Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

4.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.9K
Burn Injuries01:22

Burn Injuries

3.2K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
3.2K
Mutations01:35

Mutations

41.4K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
41.4K
Biological Effects of Radiation02:59

Biological Effects of Radiation

16.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
16.3K
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

4.5K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

537
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
537

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expert Consensus on the Elements Needed for the Design of a Long-Term Population Health Study After the Detonation of an Improvised Nuclear Device.

Disaster medicine and public health preparedness·2026
Same author

The Importance of Medical Preparedness for Radiation Emergencies.

Disaster medicine and public health preparedness·2026
Same author

Re-envisioning the North American Biodosimetry Assessment Networking Group.

Disaster medicine and public health preparedness·2026
Same author

Health Care Systems: Responsibilities and Resilience.

Disaster medicine and public health preparedness·2026
Same author

Cytogenetic Effects of Conventional and Ultra High Dose Rates of Radiation in Human Lymphocytes: Comparative Analysis in Metaphase Chromosomes and G2-PCCs.

Disaster medicine and public health preparedness·2025
Same author

Advanced Medical Countermeasures and Devices for Use During a Radiological or Nuclear Emergency.

Disaster medicine and public health preparedness·2025

Related Experiment Video

Updated: Oct 21, 2025

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.8K

Cutaneous and local radiation injuries.

Carol J Iddins1, Andrea L DiCarlo2, Mark D Ervin1

  • 1Radiation Emergency Assistance Center/Training Site (REAC/TS), Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN, United States of America.

Journal of Radiological Protection : Official Journal of the Society for Radiological Protection
|September 6, 2021
PubMed
Summary

This article reviews radiation-induced injuries to skin, deeper tissues, and organs, focusing on cutaneous radiation injuries (CRI) and their management. It highlights the need for further research into these less-understood radiation effects.

Keywords:
animal modelscutaneous radiation injury (CRI)cutaneous radiation syndrome (CRS)local radiation injury (LRI)medical countermeasuresnuclearradiological

More Related Videos

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
06:21

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

8.3K
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.4K

Related Experiment Videos

Last Updated: Oct 21, 2025

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis
07:08

Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis

Published on: August 31, 2022

1.8K
Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model
06:21

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

8.3K
Intestinal Epithelial Regeneration in Response to Ionizing Irradiation
09:10

Intestinal Epithelial Regeneration in Response to Ionizing Irradiation

Published on: July 27, 2022

2.4K

Area of Science:

  • Medical Sciences
  • Radiation Biology
  • Emergency Medicine

Background:

  • Large-scale radiological or nuclear (R/N) incidents pose a significant threat, impacting numerous individuals.
  • While acute radiation syndrome (ARS) is recognized, radiation-induced skin injuries are less understood.
  • Cutaneous radiation injuries (CRI) can occur from various R/N events and may lead to cutaneous radiation syndrome, a subset of ARS.

Purpose of the Study:

  • To provide a comprehensive overview of radiation-induced injuries to the skin, deeper tissues, and organs.
  • To detail the history, nomenclature, types, causes, pathophysiology, diagnosis, and management of CRI.
  • To discuss current research and identify existing gaps in the evaluation and management of these injuries.

Main Methods:

  • Literature review and synthesis of existing knowledge on radiation-induced injuries.
  • Presentation of historical context and classification of injury types.
  • Discussion of diagnostic approaches and current/emerging therapeutic strategies.

Main Results:

  • CRI, a significant concern in R/N incidents, are often sub-syndromes of ARS.
  • Diagnosis relies on scenario, clinical presentation, dosimetry, and advanced imaging.
  • Multidisciplinary, research-based therapies show promise for future management.

Conclusions:

  • Significant progress has been made in understanding, diagnosing, and managing radiation-induced injuries.
  • Further research is crucial to address existing knowledge gaps, particularly concerning CRI.
  • Effective management requires a multidisciplinary approach integrating laboratory and clinical findings.