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Related Experiment Video

Updated: Oct 21, 2025

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
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Mobile Spine Osseous Sarcoma: Descriptive Epidemiological Analysis Based on a National Population-Based Study.

Adel Ebrahimpour1,2, Mohammadreza Chehrassan1,2, Mehrdad Sadighi1,2

  • 1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Archives of Iranian Medicine
|September 7, 2021
PubMed
Summary

Ewing sarcoma is the most common primary bone cancer of the mobile spine in Iran, predominantly affecting males. This study provides crucial epidemiological data on rare spinal sarcomas.

Keywords:
Osseous sarcomaPrimary tumorSpine sarcomaVertebral sarcoma

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Area of Science:

  • Oncology
  • Epidemiology
  • Orthopedic Oncology

Background:

  • Primary osseous sarcomas of the mobile spine are rare bony tumors.
  • Ewing sarcoma, chondrosarcoma, chordoma, and osteosarcoma are the most common types.
  • Epidemiological studies using national registries are essential for understanding these rare conditions.

Purpose of the Study:

  • To conduct an epidemiological study of primary osseous sarcomas of the mobile spine in Iran.
  • To analyze the incidence and characteristics of these rare spinal tumors.

Main Methods:

  • A population-based study utilizing data from the Iran National Cancer Registry (INCR).
  • Analysis of all morphology codes (M-Code) for primary osseous sarcomas of the mobile spine (C-code 41.2).

Main Results:

  • 186 cases of primary osseous sarcomas of the mobile spine were identified.
  • The age-standardized incidence rate (ASIR) was 0.37 per million, with a male predilection (67.2%).
  • Ewing sarcoma was most frequent (29.5%), predominantly in the 20-25 age group; chordoma median age was 54.0 years.

Conclusions:

  • Ewing sarcoma is the most frequent primary osseous sarcoma of the mobile spine in Iran.
  • A male predilection exists for all major spinal sarcomas.
  • Ewing sarcoma in Iran presents in slightly older individuals compared to other global studies.