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Inflammatory Molecular Mediators and Pathways Involved in Vascular Aging and Stroke: A Comprehensive Review

Amro M Soliman1, Srijit Das2, Pasuk Mahakkanukrauh3

  • 1Department of Biological Sciences, Physiology, Cell and Developmental Biology, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Current Medicinal Chemistry
|September 7, 2021
PubMed

Insights

Vascular aging, driven by chronic inflammation, contributes to cardiovascular diseases. Understanding inflammatory pathways offers potential drug targets to slow aging and prevent heart conditions.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Gerontology

Background:

  • Cardiovascular diseases (CVDs) increase with age, posing a global health challenge.
  • Key age-related CVDs include atherosclerosis, myocardial infarction, hypertension, and stroke.
  • Chronic inflammation is a significant factor in age-related vascular diseases.

Purpose of the Study:

  • To elucidate the molecular mechanisms of persistent inflammation in blood vessels.
  • To identify signaling pathways involved in vascular aging.
  • To highlight potential therapeutic targets for age-related vascular disorders.

Main Methods:

  • Conducted a literature search across PubMed, ISI, Web of Science (WoS), and Scopus databases.
  • Focused on recent findings regarding inflammatory mediators and pathways in vascular aging.
  • Synthesized information on the pathogenesis and progression of vascular aging.

Main Results:

  • Identified various inflammatory mediators contributing to vascular aging.
  • Highlighted key signaling pathways implicated in age-related vascular disorders.
  • Confirmed the role of chronic inflammation in the progression of vascular aging.

Conclusions:

  • Understanding molecular mechanisms of vascular aging is crucial for developing interventions.
  • Identified inflammatory mediators and pathways represent potential drug targets.
  • Targeting these pathways may inhibit or slow the progression of vascular aging and associated CVDs.

Keywords:
Cardiovascularatherosclerosisinflammationinflammatory mediatorsstrokevascular aging

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