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Delayed pubarche.

Francesco Baldo1, Egidio Barbi2,3, Gianluca Tornese3

  • 1Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazzale Europa 1, 34127, Trieste, Italy. francescobaldo11@yahoo.it.

Italian Journal of Pediatrics
|September 7, 2021
PubMed
Summary
This summary is machine-generated.

Delayed pubarche in adolescents is usually benign, stemming from a gonadarche-adrenarche timing difference. However, other symptoms may indicate hormonal deficiencies or genetic conditions requiring further investigation.

Keywords:
AbsentAdolescentAdrenarchePathologicalPubarche

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Area of Science:

  • Pediatric Endocrinology
  • Adolescent Health
  • Reproductive Medicine

Background:

  • Delayed pubarche, the onset of pubic hair development, is common in adolescents.
  • It often results from a physiological timing difference between gonadarche and adrenarche.

Purpose of the Study:

  • To outline the differential diagnosis of delayed pubarche in adolescents.
  • To highlight potential underlying causes beyond physiological timing differences.

Main Methods:

  • Review of clinical presentations associated with delayed pubarche.
  • Analysis of diagnostic approaches including hormonal assays, genetic testing, and imaging.

Main Results:

  • Delayed pubarche can be benign in healthy adolescents due to physiological timing discrepancies.
  • In symptomatic cases, causes include hormone deficiencies (adrenal insufficiency, panhypopituitarism, hypothyroidism) and genetic conditions (Turner syndrome, androgen insensitivity syndrome).
  • Exposure to endocrine disruptors is also a potential factor.

Conclusions:

  • While often benign, delayed pubarche warrants careful evaluation when accompanied by other clinical signs.
  • Basic blood tests, karyotyping, and initial imaging are crucial for accurate differential diagnosis.