Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

3.4K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Socioeconomic inequalities and health behaviours in depression: a picture of mental health in Portugal.

European journal of public health·2026
Same author

Concept Cells and the Neural Bases of Human Memory.

Acta physiologica (Oxford, England)·2026
Same author

Daily-Life, Sensor-Derived Tremor Measures Are Sensitive to Progression in Early Parkinson's Disease.

Annals of neurology·2026
Same author

Driving theta-gamma oscillations modulates short interval intracortical inhibition: a tACS-TMS study.

Brain stimulation·2026
Same author

Dithering suppresses half-harmonic neural synchronisation to photic stimulation in humans.

Brain stimulation·2026
Same author

Frequency-specific and spatiotemporal dynamics of β-γ phase-amplitude coupling in Parkinson's disease.

Brain : a journal of neurology·2026

Related Experiment Video

Updated: Oct 21, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.3K

Essential tremor amplitude modulation by median nerve stimulation.

Carolina Reis1, Beatriz S Arruda1, Alek Pogosyan1

  • 1Medical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 3TH, UK.

Scientific Reports
|September 7, 2021
PubMed
Summary

This study explored non-invasive electrical stimulation for essential tremor. Phase-locked peripheral stimulation showed subtle tremor modulation in some patients, suggesting potential for personalized treatment strategies.

More Related Videos

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
07:53

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

22.2K
Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

9.1K

Related Experiment Videos

Last Updated: Oct 21, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.3K
Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
07:53

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

22.2K
Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

9.1K

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Neuroscience

Background:

  • Essential tremor is a prevalent neurological disorder causing involuntary limb shaking.
  • Current treatments like medications have limited efficacy and potential side effects.
  • Surgical options are effective but invasive and costly, limiting patient access.

Purpose of the Study:

  • To investigate a non-invasive, closed-loop electrical stimulation paradigm for essential tremor.
  • To assess the feasibility of tracking peripheral tremor and targeting thalamic afferents.
  • To modulate central oscillators responsible for tremor generation.

Main Methods:

  • Electrical stimulation delivered to the median nerve in 9 patients.
  • Stimulation was phase-locked to different phases of the tremor.
  • Peripheral stimulation effects on tremor amplitude were analyzed.

Main Results:

  • Subtle but significant tremor modulation observed in 5 out of 9 patients.
  • Modulation primarily involved tremor amplitude amplification, not suppression.
  • Effects were more pronounced when tremor was weaker at stimulation onset.

Conclusions:

  • Non-invasive, tremor phase-locked peripheral stimulation shows potential for essential tremor management.
  • Personalized control strategies considering tremor phase and amplitude are recommended for future research.
  • This approach may offer a viable alternative for selected patients unresponsive to conventional therapies.