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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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KRAS-related long noncoding RNAs in human cancers.
Mahsa Saliani1,2, Amin Mirzaiebadizi1, Ali Javadmanesh3,4
1Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Cancer Gene Therapy
|September 7, 2021
Summary
Long noncoding RNAs (lncRNAs) regulate microRNAs (miRNAs) targeting the KRAS oncogene. This review highlights lncRNAs as key mediators of KRAS expression in cancer, crucial for diagnosis and treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- KRAS is a prevalent proto-oncogene implicated in numerous human cancers.
- Constitutively active KRAS oncoprotein drives tumor initiation and progression via MAPK pathway.
- Dysregulation of microRNAs (miRNAs) and KRAS oncogene expression is common in cancers.
Purpose of the Study:
- To review recent research on long noncoding RNAs (lncRNAs) that sponge KRAS-targeting miRNAs.
- To elucidate the role of lncRNAs as crucial mediators of KRAS expression.
- To highlight the significance of lncRNAs in KRAS-driven cancers for clinical applications.
Main Methods:
- Literature review of recent scientific articles.
- Analysis of studies focusing on lncRNA-miRNA interactions.
- Synthesis of findings on lncRNA regulation of KRAS expression.
Main Results:
- lncRNAs act as sponges for miRNAs that target the KRAS oncogene.
- These lncRNAs play critical roles in modulating KRAS expression in various cell types and organs.
- lncRNAs are emerging as significant regulators in KRAS-driven oncogenesis.
Conclusions:
- Understanding lncRNA sponging of KRAS-targeting miRNAs is fundamental for KRAS-driven cancers.
- lncRNAs represent promising biomarkers for cancer diagnosis and prognosis.
- lncRNAs offer potential therapeutic targets for cancer treatment.
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