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Neurochip3: An Autonomous Multichannel Bidirectional Brain-Computer Interface for Closed-Loop Activity-Dependent
Larry E Shupe1,2, Frank P Miles2, Geoff Jones3
1Department of Physiology & Biophysics, University of Washington, Seattle, WA, United States.
Frontiers in Neuroscience
|September 7, 2021
Summary
The Neurochip3 (NC3) is a compact, autonomous brain-computer interface enabling closed-loop stimulation for neuroprosthetics. It supports activity-dependent paradigms to enhance brain function and connections.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Neuroprosthetics
Background:
- Brain-computer interfaces (BCIs) are crucial for neuroprosthetic applications.
- Developing autonomous, closed-loop systems is essential for advanced neuroprosthetic functionality.
- Previous BCI iterations have shown promise but require further development for practical applications.
Purpose of the Study:
- To introduce the Neurochip3 (NC3), a multichannel bidirectional brain-computer interface.
- To detail the NC3's components, functionality, and autonomous operation capabilities.
- To highlight the NC3's utility in closed-loop stimulation for neuroprosthetic and neurorehabilitation applications.
Main Methods:
- The Neurochip3 (NC3) integrates an analog front-end, digital control system, high-capacity storage, a stimulator, a battery pack, and communication ports.
- Utilizes off-the-shelf components for a compact, head-mountable design suitable for non-human primates (NHPs).
- Incorporates a 16-channel amplifier, FPGA and MCU for control, 128GB+ storage, and a 6-channel stimulator with ±60 V compliance.
Main Results:
- The NC3 facilitates autonomous operation for up to 24 hours.
- Successfully deployed in closed-loop operations to induce synaptic plasticity and bridge neural connections.
- Demonstrated effectiveness in delivering activity-dependent intracranial reinforcement for neuroprosthetic applications.
Conclusions:
- The Neurochip3 (NC3) is a versatile and autonomous BCI system for advanced neuroprosthetic applications.
- Its closed-loop capabilities support paradigms for strengthening or replacing impaired neural connections.
- NC3 shows significant potential in neurorehabilitation and advancing brain-computer interface technology.
