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RNA Methylations in Cardiovascular Diseases, Molecular Structure, Biological Functions and Regulatory Roles in

Wanwan Zhou1, Changhui Wang2, Jun Chang3

  • 1Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.

Frontiers in Pharmacology
|September 7, 2021
PubMed

Insights

RNA methylations, including m6A, are crucial in cardiovascular diseases (CVDs). Understanding these RNA modifications offers new diagnostic and therapeutic targets for heart conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) remain a leading global cause of death.
  • Current diagnostic and therapeutic strategies for CVDs require enhancement.
  • RNA modifications, particularly methylation, play vital roles in cellular processes.

Purpose of the Study:

  • To review the molecular structures and biological functions of five RNA methylations: m6A, m5C, m1a, m6am, and m7G.
  • To examine the effects of these RNA methylations on various cardiovascular diseases.
  • To highlight RNA methylation as a potential area for novel CVD biomarkers and therapies.

Main Methods:

  • Literature review focusing on the roles of RNA methylations in CVD pathogenesis.
  • Analysis of the mechanisms involving RNA methylation 'writers', 'erasers', and 'readers'.
  • Synthesis of current knowledge on m6A, m5C, m1a, m6am, and m7G in cardiovascular conditions.

Main Results:

  • RNA methylations significantly impact RNA processing, including nuclear export, translation, and splicing.
  • The m6A modification, regulated by writers, erasers, and readers, influences mRNA fate in CVDs.
  • Emerging roles of m5C, m1a, m6am, and m7G in CVDs warrant further investigation.

Conclusions:

  • RNA methylations are increasingly recognized as critical players in cardiovascular pathophysiology.
  • Further research into RNA methylation mechanisms can uncover new diagnostic markers for CVDs.
  • Targeting RNA methylation pathways presents a promising avenue for developing innovative therapeutic strategies for cardiovascular diseases.

Keywords:
RNA methylationcardiovascular diseasem5Cm6Apulmonary hypertension

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