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Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Hua Guan1,2, Jin Zhang3, Jing Luan1,4

  • 1State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Anethesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China.

Frontiers in Endocrinology
|September 7, 2021
PubMed

Insights

Secreted frizzled related proteins (SFRPs) are key regulators of Wnt signaling implicated in metabolic diseases. This review details SFRPs

Area of Science:

  • Molecular Biology
  • Endocrinology
  • Biochemistry

Background:

  • Abnormal gene expression and protein levels correlate with pathological changes.
  • Secreted frizzled related proteins (SFRPs) antagonize the Wnt signaling pathway.
  • SFRPs are increasingly recognized for their role in metabolic disease pathogenesis.

Purpose of the Study:

  • To provide a comprehensive overview of SFRPs.
  • To explore SFRPs' structural characteristics, receptors, inhibitors, and signaling pathways.
  • To examine SFRPs' impact on metabolic diseases like obesity, type 2 diabetes, and cardiovascular conditions.

Main Methods:

  • Literature review of existing research on SFRPs.
  • Analysis of structural and functional properties of SFRP family members.
  • Synthesis of data on SFRPs' involvement in metabolic disease pathologies and molecular mechanisms.

Main Results:

  • SFRPs play a significant role in lipid metabolism, obesity, type 2 diabetes mellitus, and cardiovascular diseases.
  • Detailed insights into the molecular mechanisms underlying SFRPs' involvement in metabolic disorders.
  • Identification of SFRPs' structural features, interactions, and pathway modulation.

Conclusions:

  • SFRPs are crucial in regulating metabolic processes and are implicated in various metabolic diseases.
  • SFRPs hold potential as therapeutic targets for metabolic diseases.
  • SFRPs may serve as valuable biomarkers for diagnosing and monitoring metabolic conditions.
Keywords:
SFRPsadipocytecardiovascular diseasemetabolism diseaseobesity

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