Zebrafish Models for Human Skeletal Disorders

Area of Science:

• Genetics
• Developmental Biology
• Pharmacology

Background:

• The International Skeletal Dysplasia Society updated its classification of genetic skeletal disorders in 2019.
• Understanding the genetic basis of these disorders is crucial for diagnosis and research.
• Zebrafish offer a valuable model system for studying human skeletal diseases.

Purpose of the Study:

• To review the current state of zebrafish models for genetic skeletal disorders.
• To align zebrafish research with the 2019 Nosology and Classification of Genetic Skeletal Disorders.
• To encourage research that bridges the gap between zebrafish studies and clinical applications.

Main Methods:

• Review of existing literature on zebrafish models for skeletal dysplasias.
• Categorization of zebrafish models based on the 2019 Nosology Committee's classification.
• Analysis of the 'aquarium to bedside' approach in this field.

Main Results:

• Over 80 zebrafish models for skeletal disorders are currently available.
• Zebrafish models provide a cost-effective and versatile platform for research.
• The review systematically presents these models according to the established nosology.

Conclusions:

• Zebrafish research is a promising avenue for developing treatments for human skeletal dysplasias.
• Aligning research with clinical nosology is essential for translational success.
• Further research is needed to fully leverage zebrafish models for clinical benefit.