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Related Experiment Video

Updated: Oct 21, 2025

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
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Oral Microbiota Composition and Function Changes During Chronic Erythematous Candidiasis.

Xin Lyu1, Hui Zheng2, Xu Wang1,2

  • 1Department of Oral Medicine, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, Beijing, China.

Frontiers in Cellular and Infection Microbiology
|September 7, 2021
PubMed
Summary
This summary is machine-generated.

The oral microbiome differs significantly in chronic erythematous candidiasis patients compared to healthy individuals. Specific bacteria like Rothia mucilaginosa and Streptococcus mitis were enriched, suggesting the oral microbiome as a therapeutic target.

Keywords:
Candida albicansfunctional potentialsmetagenomicsoral candidiasisoral microbiota

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Area of Science:

  • Microbiology
  • Oral Health
  • Metagenomics

Background:

  • The oral microbiome plays a crucial role in host health, but its composition in chronic erythematous candidiasis is not well understood.
  • Understanding these microbial shifts is essential for developing targeted treatments.

Purpose of the Study:

  • To compare oral microbial signatures and functional profiles between chronic erythematous candidiasis patients and healthy subjects.
  • To identify specific microbial species and genes associated with chronic erythematous candidiasis.

Main Methods:

  • Shotgun metagenomic sequencing was employed to analyze salivary microbiome samples.
  • 12 chronic erythematous candidiasis patients, 12 healthy controls, and 2 cured patients were included.
  • Co-occurrence network analysis was used to examine interactions between Candida albicans and oral bacteria.

Main Results:

  • Salivary microbiota composition significantly differed between chronic erythematous candidiasis patients and healthy subjects.
  • Rothia mucilaginosa and Streptococcus mitis were identified as the most abundant disease-enriched species.
  • Candida albicans showed strong co-occurrence with oral bacteria, particularly Streptococcus species.
  • Microbial marker genes associated with eukaryotic ribosome, glutamine transport, and respiration were enriched in patients.

Conclusions:

  • The study reveals distinct oral microbial compositions and functional potentials in chronic erythematous candidiasis.
  • These findings highlight the potential of the oral microbiome as a target for therapeutic interventions and prevention strategies.
  • Specific bacterial species and functional genes are linked to the disease state, offering insights for future research.