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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Relationship Between Serum Albumin and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis

Yali Wang1, Peng Du2, Qi Xiao2

  • 1Department of Pathology, The Affiliated Stomatological Hospital of Nanchang University, Nanchang, China.

Frontiers in Nutrition
|September 7, 2021
PubMed

Insights

Low serum albumin levels are linked to a higher risk of atrial fibrillation. Increasing albumin may reduce this risk, suggesting a potential preventative role.

Area of Science:

  • Cardiology
  • Biochemistry
  • Epidemiology

Background:

  • The relationship between serum albumin and atrial fibrillation (AF) risk is not fully understood.
  • This study investigates the association and dose-response effect of serum albumin on AF.
  • Existing research lacks comprehensive analysis of this specific link.

Approach:

  • A meta-analysis of nine studies involving 32,130 participants was conducted.
  • Literature searches were performed using EMBASE, PubMed, and Cochrane Library databases.
  • Dose-response analysis utilized robust error meta-regression to evaluate the albumin-AF relationship.

Key Points:

  • Higher serum albumin levels were associated with a reduced risk of atrial fibrillation (OR: 0.62).
  • Each 10 g/L increase in serum albumin correlated with a 36% decrease in AF risk.
  • A significant negative linear relationship was observed between serum albumin and AF risk.

Conclusions:

  • Low serum albumin is associated with an increased risk of atrial fibrillation.
  • This meta-analysis highlights a dose-response relationship between albumin levels and AF.
  • Further research is warranted to explore therapeutic interventions targeting albumin levels for AF prevention.

Keywords:
albuminatrial fibrillationdose-responsenutritionrisk factor

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