Relationship between high-sensitivity cardiac troponin T, B-type natriuretic peptide, and physical function in
Kensuke Ueno1, Kentaro Kamiya1,2, Nobuaki Hamazaki3
1Department of Rehabilitation Sciences, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Insights
Higher levels of high-sensitivity cardiac troponin T (hs-cTnT) and B-type natriuretic peptide (BNP) are linked to reduced physical function in heart failure (HF) patients. hs-cTnT showed a stronger association, suggesting its utility in assessing physical function in HF.
Area of Science:
- Cardiology
- Biomarkers
- Heart Failure Research
Background:
- High-sensitivity cardiac troponin T (hs-cTnT) and B-type natriuretic peptide (BNP) are established prognostic markers in heart failure (HF).
- The relationship between these biomarkers and objective measures of physical function in HF patients remains incompletely understood.
Purpose of the Study:
- To investigate the association between hs-cTnT and BNP levels and physical function in patients diagnosed with heart failure.
- To determine if hs-cTnT and BNP can predict limitations in physical performance in this population.
Main Methods:
- Evaluated hs-cTnT, BNP, maximal quadriceps isometric strength (QIS), usual gait speed, and 6-min walk distance (6MWD) in 363 HF patients.
- Patients were stratified into four groups based on median hs-cTnT and BNP levels.
- Statistical analyses adjusted for demographic factors, laboratory results, and HF severity.
Main Results:
- Elevated hs-cTnT and BNP levels were significantly associated with decreased QIS, usual gait speed, and 6MWD.
- hs-cTnT demonstrated a more consistent inverse relationship with all measured physical function parameters.
- Patients in the high hs-cTnT and high BNP group exhibited significantly poorer physical function compared to those in the low hs-cTnT and low BNP group.
Conclusions:
- Both hs-cTnT and BNP are independently associated with reduced physical function in heart failure patients.
- hs-cTnT appears to be a more robust predictor of physical function deficits than BNP.
- Combined assessment of hs-cTnT and BNP may enhance the stratification of physical function capacity in individuals with HF.
Aims:
High-sensitivity cardiac troponin T (hs-cTnT) and B-type natriuretic peptide (BNP) are associated with prognosis and severity in patients with heart failure (HF); however, their association with physical function is unclear. This study aimed to investigate whether hs-cTnT and BNP levels are associated with physical function in patients with HF.
Methods And Results:
Hs-cTnT, BNP, and physical function (maximal quadriceps isometric strength [QIS], usual gait speed, and 6-min walk distance [6MWD]) were evaluated in 363 consecutive patients with HF (median age, 70 [60-78] years). Patients were divided into four groups according to their median hs-cTnT and BNP levels. After adjusting for demographic characteristics, laboratory levels, and HF severity, higher hs-cTnT and BNP levels were significantly associated with lower physical function (log hs-cTnT, β = -0.162, P = 0.001, for maximal QIS; β = -0.175, P = 0.002, for usual gait speed, and β = -0.129, P = 0.004, for 6MWD; log BNP, β = -0.090, P = 0.092, for maximal QIS, β = 0.038, P = 0.516, for usual gait speed, and β = -0.108, P = 0.023, for 6MWD). In addition, the high hs-cTnT and high BNP group had significantly lower physical function (all P < 0.05) than the low hs-cTnT and low BNP group.
Conclusions:
Higher hs-cTnT and BNP levels are both associated with lower physical function in patients with HF, but hs-cTnT levels showed a more consistent association. The combination of hs-cTnT and BNP may be effective for the stratification of physical function in patients with HF.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:29Heart Failure II: Pathophysiology
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Heart Failure VII: Nursing Interventions
01:17Pathophysiology of Heart Failure
01:30Heart Failure IV: Classification and Diagnostic Evaluation