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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Related Experiment Video

Updated: Oct 21, 2025

Author Spotlight: A Novel 3D-Printed Titanium Implant for Minimally Invasive Treatment of Hip Dysplasia in Young Dogs
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Hypertrophic osteodystrophy in dogs.

J Selman1, H Towle Millard1

  • 1Small Animal Surgery, BluePearl Veterinary Partners, Overland Park, Kansas, USA.

The Journal of Small Animal Practice
|September 7, 2021
PubMed
Summary

Hypertrophic osteodystrophy (HOD) is a painful orthopedic condition in young dogs with unknown causes. Diagnosis involves clinical signs and radiographic evidence of a "double physis," with treatment focusing on supportive care and pain management.

Area of Science:

  • Veterinary Orthopedics
  • Canine Pathology

Background:

  • Hypertrophic osteodystrophy (HOD) is an uncommon orthopedic disease affecting young, growing dogs.
  • The etiology of HOD remains unknown, with theories including viral infections, vaccinations, hereditary factors, and autoimmune disorders.

Purpose of the Study:

  • To summarize the clinical presentation, diagnostic methods, treatment strategies, and prognosis for canine hypertrophic osteodystrophy.

Main Methods:

  • Clinical sign assessment for suspicion of HOD.
  • Radiographic confirmation using the characteristic "double physis" finding.
  • Review of current treatment protocols and prognostic indicators.

Main Results:

  • Affected dogs exhibit lameness, lethargy, fever, and limb swelling.

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  • Radiographs reveal a radiolucent line parallel to the physis, confirming HOD.
  • Treatment success varies with severity, with mild to moderate cases having favorable prognoses.
  • Conclusions:

    • Early diagnosis and supportive care are crucial for managing hypertrophic osteodystrophy in dogs.
    • Prognosis is favorable for mild to moderate cases, but guarded for severely affected individuals.
    • Further research into HOD etiology is warranted to improve preventative strategies.