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Synthesis, chemical stability and pre-clinical anti-tumor activity of pyrazine diazohydroxide, sodium salt
D C Baker1, E S Hand, J Plowman
1Department of Chemistry, University of Alabama, Tuscaloosa 35487-9671.
Anti-Cancer Drug Design
|December 1, 1987
Abstract:
The synthesis, chemical stability and anti-tumor activity of pyrazine diazohydroxide, sodium salt, a compound that has been selected for development to clinical trials, are described. The compound shows a half-life of about 100 minutes at pH 7.4 and is active against a number of experimental tumors.