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Related Concept Videos

Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Related Experiment Video

Updated: Oct 21, 2025

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Function of Orofacial Stem Cells in Tooth Eruption: An Evolving Perspective.

Yi Yu, Chen Cui, Shu Yuan Guan

    The Chinese Journal of Dental Research
    |September 7, 2021
    PubMed
    Summary

    Stem cells play a crucial role in tooth eruption, influencing development and occlusion. Understanding orofacial stem cell functions is key to addressing eruption disturbances and maintaining oral health.

    Keywords:
    alveolar bonedental follicledental stem cellsmotive forceosteoblastsosteoclasts

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    Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor
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    Isolation and Culture of Dental Epithelial Stem Cells from the Adult Mouse Incisor
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    Area of Science:

    • Oral Biology
    • Developmental Biology
    • Stem Cell Research

    Background:

    • Tooth eruption is vital for dentition development, occlusion, and aesthetics.
    • Eruption is a complex biological process involving cellular and tissue dynamics.
    • Disturbances in tooth eruption can negatively impact oral functions and facial structure.

    Purpose of the Study:

    • To review current knowledge on orofacial stem cells in tooth eruption.
    • To highlight the characteristics and functions of various stem cell populations.
    • To focus on recent findings regarding stem cell lineage and regulation.

    Main Methods:

    • Literature review of scientific articles on tooth eruption and stem cells.
    • Synthesis of data on stem cell populations in oral tissues.
    • Analysis of regulatory mechanisms and lineage allocation in stem cell-driven eruption.

    Main Results:

    • Multiple stem cell populations (dental follicle, bone marrow, periodontal ligament, apical papilla, dental pulp) are involved in eruption.
    • These stem cells possess distinct differentiation capacities.
    • Stem cells are integral to alveolar bone remodeling, periodontium development, and root formation during eruption.

    Conclusions:

    • Orofacial stem cells are critical regulators of tooth eruption.
    • Understanding their roles and regulatory mechanisms is essential for managing eruption disorders.
    • Further research into stem cell lineage and function will advance regenerative dentistry.