Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Poisson Probability Distribution01:09

Poisson Probability Distribution

10.2K
A Poisson probability distribution is a discrete probability distribution. It gives the probability of a number of events occurring in a fixed interval of time or space if these events happen at a known average rate and independently of the time since the last event. For example, a book editor might be interested in the number of words spelled incorrectly in a particular book. It might be that, on average, there are five words spelled incorrectly in 100 pages. The interval is 100 pages.
The...
10.2K
Probability Laws01:49

Probability Laws

42.3K
Overview
42.3K
Binomial Probability Distribution01:15

Binomial Probability Distribution

13.3K
A binomial distribution is a probability distribution for a procedure with a fixed number of trials, where each trial can have only two outcomes.
The outcomes of a binomial experiment fit a binomial probability distribution. A statistical experiment can be classified as a binomial experiment if the following conditions are met:
There are a fixed number of trials. Think of trials as repetitions of an experiment. The letter n denotes the number of trials.
There are only two possible outcomes,...
13.3K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

74.4K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
74.4K
Poisson's And Laplace's Equation01:25

Poisson's And Laplace's Equation

3.6K
The electric potential of the system can be calculated by relating it to the electric charge densities that give rise to the electric potential. The differential form of Gauss's law expresses the electric field's divergence in terms of the electric charge density.
3.6K
Poisson's Ratio01:23

Poisson's Ratio

643
Poisson's ratio is a material property that indicates their stress response. It explains the connection between the elongation or compression a material undergoes in the direction of an applied force and the contraction or expansion it experiences perpendicular to that force. When a slender bar is loaded axially, it stretches in the direction of the force and contracts laterally. Poisson's ratio is the negative ratio of this lateral contraction to the axial elongation. The negative sign...
643

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the determinants of public trust in the health care system in China: an analysis of a cross-sectional survey.

Journal of health services research & policy·2018
Same author

Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth.

The Journal of pediatrics·2018
Same author

LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1.

Pathology, research and practice·2018
Same author

International variations in trust in health care systems.

The International journal of health planning and management·2018
Same author

Toll-like receptor 9 negatively regulates pancreatic islet beta cell growth and function in a mouse model of type 1 diabetes.

Diabetologia·2018
Same author

Methylation in OTX2 and related genes, maltreatment, and depression in children.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2018
Same journal

GMSA: A Graph Matching and Point Cloud Registration-Based Method for Spatial Transcriptomics Data Alignment.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Investigations on Multiple Protein Scaffold Filling.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Cell Type Prediction for Single-Cell RNA Sequencing Utilizing Unsupervised Domain Adaptation and Semi-Supervised Learning.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

PPIGAN: Prediction of Protein-Protein Interactions Using Generative Adversarial Networks.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Deep Structure-Enhanced Cell Clustering Model for Single-Cell RNA Sequencing Data.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Asymmetric Drug-Drug Interaction Prediction Based on Generative Adversarial Networks and Knowledge Graph.

Journal of computational biology : a journal of computational molecular cell biology·2026
See all related articles

Related Experiment Video

Updated: Oct 21, 2025

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
08:23

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

3.8K

Calculating Orthologous Protein-Coding Sequence Set Probability Using the Poisson Process.

Junfeng Liu1, Yi Wang2, Hongyu Zhao3

  • 1School of Mathematics and Information Sciences, Yantai University, Yantai, P.R. China.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|September 7, 2021
PubMed
Summary
This summary is machine-generated.

This study extends the Jukes-Cantor model to calculate orthologous nucleotide sequence probabilities. Asexual lineages show significantly faster mutation rates than their sexual relatives.

Keywords:
Poisson processcodonnucleotideorthologueprobabilityprospectiveretrospective

More Related Videos

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.6K
A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.4K

Related Experiment Videos

Last Updated: Oct 21, 2025

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data
08:23

De novo Identification of Actively Translated Open Reading Frames with Ribosome Profiling Data

Published on: February 18, 2022

3.8K
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.6K
A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.4K

Area of Science:

  • Computational Biology
  • Evolutionary Biology
  • Genomics

Background:

  • The Jukes-Cantor model is a foundational tool for understanding nucleotide sequence evolution.
  • Accurate modeling of sequence evolution is crucial for phylogenetic analysis and understanding genetic diversity.

Purpose of the Study:

  • To extend the Jukes-Cantor model for calculating orthologous nucleotide sequence probabilities.
  • To develop algorithms for estimating ancestral sequences and evolutionary event probabilities.
  • To compare mutation rates between asexual and sexual lineages.

Main Methods:

  • Extension of the Jukes-Cantor model incorporating Poisson process for sequence evolution.
  • Development of algorithms using retrospective processes and Monte Carlo integration.
  • Application of event queue sampling and probability magnifiers for computational efficiency.
  • Analysis of simulated data and hexapod transcriptome data.

Main Results:

  • The developed procedure successfully calculates orthologous nucleotide sequence probabilities.
  • Asexual lineages were found to mutate several times faster than their sexual counterparts.
  • Model comparison supported the higher mutation rate in asexual lineages.

Conclusions:

  • The extended Jukes-Cantor model provides a robust framework for analyzing sequence evolution.
  • Asexual reproduction may be associated with accelerated mutation rates compared to sexual reproduction.
  • Findings have implications for understanding genome evolution and diversification in various taxa.