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[The exposome: Tensions between holism and reductionism]
Élodie Giroux1, Yohan Fayet2, Thibaut Serviant-Fine3
1Faculté de philosophie, Université Jean Moulin Lyon 3, Palais de l'université, 15 quai Claude-Bernard, 69007 Lyon, France - Institut de recherches philosophiques de Lyon, EA 4187, Lyon, France - Laboratoire SPHere, UMR 7219, Paris, France.
Medecine Sciences : M/S
|September 7, 2021
Summary
The exposome concept offers a unified approach to environmental health research by integrating biological, environmental, and social data. This holistic method aims for precise exposure analysis using biomarkers to understand disease origins.
Area of Science:
- Environmental Health Sciences
- Biomarker Research
- Public Health
Background:
- The post-genomics era necessitates integrated approaches to environmental health.
- Christopher Wild introduced the exposome concept for a unified exposure assessment.
- Current research faces challenges integrating diverse data and disciplinary fields.
Purpose of the Study:
- To analyze the exposome concept and its potential.
- To explore the interplay between holism and reductionism in exposure science.
- To identify novel concepts for understanding disease etiology.
Main Methods:
- Conceptual analysis of the exposome framework.
- Literature review on integrated environmental health research.
- Exploration of biomarker identification for exposure assessment.
Main Results:
- The exposome concept facilitates the integration of biological, environmental, and social data.
- It supports practical interactions within environmental health research.
- Novel concepts like 'embodiment' and 'sociomarkers' emerge for etiological understanding.
Conclusions:
- The exposome approach offers a powerful, integrative framework for environmental health.
- It advances precise exposure analysis through biomarkers.
- This concept fosters new understandings of disease causation by bridging disciplines.
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