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Related Experiment Video

Updated: Oct 21, 2025

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Giant cell arteritis with spontaneous remission.

Bonifacio Álvarez-Lario¹, José Andrés Lorenzo-Martín¹, María Colazo-Burlato¹

¹Rheumatology Department, Hospital Universitario de Burgos, Burgos, Spain.

Modern Rheumatology Case Reports

|September 7, 2021

Summary

Polymyalgia rheumatica (PMR) can progress to giant cell arteritis (GCA) years later. This case highlights GCA

Keywords:

Giant cell arteritis polymyalgia rheumatica spontaneous remission temporal arteritis temporal artery biopsy complications

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Area of Science:

Rheumatology
Internal Medicine

Background:

Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are common in older adults.
PMR and GCA often coexist and share inflammatory pathways.

Observation:

A 75-year-old woman with PMR in remission developed GCA symptoms including headache and diplopia.
Symptoms spontaneously resolved, but ultrasound showed temporal artery abnormalities.
A temporal artery biopsy was unsuccessful and complicated by facial nerve injury.

Findings:

Diagnosis of GCA was confirmed by clinical, laboratory, and ultrasound findings.
The patient achieved remission with prednisone and methotrexate treatment.
The case presents spontaneous GCA remission and diagnostic challenges.

Implications:

This case underscores the importance of monitoring PMR patients for GCA development.
It highlights diagnostic difficulties and potential complications of temporal artery biopsy.
The case contributes to understanding GCA's varied clinical presentations and management.