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Updated: Oct 21, 2025

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

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Magnesium intake and vascular structure and function: the Hoorn Study

Emma A Vermeulen1, Hanne B T de Jong2, Alexander G A Blomjous3

  • 1Department of Nephrology, Amsterdam UMC, Location VUmc, Amsterdam, The Netherlands.

European Journal of Nutrition
|September 7, 2021
PubMed

Insights

Dietary magnesium intake was not associated with vascular health markers like arterial stiffness or blood vessel function in a prospective study. This suggests magnesium

Area of Science:

  • Cardiovascular Science
  • Nutritional Epidemiology
  • Vascular Biology

Background:

  • Dietary and circulating magnesium are linked to reduced cardiovascular disease (CVD) and mortality.
  • Understanding magnesium's role in vascular health is crucial for preventive strategies.

Purpose of the Study:

  • To investigate the association between dietary magnesium intake and vascular structure/function markers.
  • To analyze cross-sectional and longitudinal relationships in a prospective cohort.

Main Methods:

  • Included 789 participants from the Hoorn Study vascular screening sub-cohort.
  • Dietary magnesium intake assessed via food frequency questionnaire, categorized into tertiles.
  • Vascular measures (IMT, Aix, PWV, FMD, PAD) assessed at baseline and follow-up (8 years).
  • Multivariable regression models used for cross-sectional and longitudinal analyses.

Main Results:

  • No significant associations were found between dietary magnesium intake and vascular outcomes.
  • Highest vs. lowest magnesium intake tertiles showed no difference in PWV, FMD, IMT, Aix, or PAD risk.
  • Mean magnesium intake was 328 mg/day; 55% had prior CVD and 41% had type 2 diabetes (DM2).

Conclusions:

  • Dietary magnesium intake did not correlate with key markers of vascular structure and function.
  • Findings suggest no direct link between magnesium consumption and vascular health in this cohort.
Abstract

Keywords:
Augmentation indexFlow-mediated dilatationIntima-media thicknessMagnesium intakePeripheral arterial diseasePulse wave velocity

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