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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Clinical difference between single subtype and mixed subtype chronic urticaria: A retrospective study.

Manyun Mao1, Yan Yuan1, Yangjian Xiao1

  • 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Indian Journal of Dermatology, Venereology and Leprology
|September 7, 2021
PubMed
Summary

Mixed subtype chronic urticaria presents distinct features, including a female predominance and increased urticaria activity. Treatment with antihistamines is less effective in these patients, highlighting the need for tailored therapeutic strategies.

Keywords:
Chronic inducible urticariachronic spontaneous urticariahistamine H1 antagonists

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Chronic urticaria (CU) subtypes share clinical presentation but differ phenotypically.
  • Patients may have coexisting CU subtypes with varying phenotypes.

Purpose of the Study:

  • To compare single versus mixed subtype chronic urticaria.
  • Evaluate differences in demographics, clinical profiles, and treatment responses.

Main Methods:

  • Retrospective study of 2678 chronic urticaria patients.
  • Categorized patients into single or mixed subtype groups.
  • Assessed clinical features, causes, disease activity, quality of life, and treatment outcomes.

Main Results:

  • Mixed subtype CU, comprising 31.25% of patients, showed female predominance.
  • Chronic spontaneous urticaria with symptomatic dermographism was most common in mixed subtype.
  • Mixed subtype patients experienced more chest tightness/shortness of breath and greater urticaria activity.
  • Lower positive family history rates for allergic rhinitis, asthma, or urticaria in single subtype.
  • Second-generation antihistamine control was lower in mixed (38.83%) vs. single (56.32%) subtype CU.

Conclusions:

  • Mixed subtype chronic urticaria exhibits distinct characteristics.
  • Understanding these differences can guide effective therapeutic strategies.
  • Improved symptom control and quality of life are potential outcomes.